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Main Areas of Interest: Immunology, immunopathology, immunophysiology neuroimmunology. Mucosal immunology and its alteration in a variety of diseases and models. The role of neuroimmune interactions in allergy and inflammation. The reciprocal communication between the nervous and immune systems. Mechanisms of action of probiotic organisms on the nervous system, behaviour and in various models of inflammation.,
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Current Projects:
- Functional role of mast cells.
- Mechanisms of action of probiotic organisms in models of asthma, and
visceral pain.
- Effects of commensal bacteria on the central and peripheral nervous systems including and behavior. Neuroimmune mechanisms.
Associated Personnel:
Administration: Kathryn Hough, Program Manager
Michele Drake, Executive Assistant/Admin. Coordinator
Post doctoral fellows: Khalil Karimi
Graduate students: Emily Escaravage and Marianne Chew
Techologists: Ula Kadela
Research Associates: Lu Wang, Yu Kang Mao
Awards and Honours:
- Fellow, The Royal Society of Canada (1992)
- Finkelstein Prize, Crohn’s and Colitis Foundation of Canada (1996)
- Distinguished University Professor, McMaster University (1997)
- Doctor (Honoris Causa) in Medicine, University of Göteborg, Sweden (1998)
- Order of Canada 2002
- Karl Hansen Medal, German Society for Allergology and Clinical Immunology (2007)
- Fellow, The Royal Society of Canada (1992)
Major Publications:
- Furuno T, Ita A, Koma Y, Watabe K, Yokozaki H, Bienenstock J, Nakanishi M, Kitamura Y. (2005): The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves. J Immunol 174: 6934-6942.
- Forsythe P, Inman MD, Bienenstock J. (2007): Oral treatment with live Lactobacillus reuteri inhibits the allergic airway response in mice. Am J Respir Crit Care Med 175: 561-69.
- Duncker SC, Wang L, Hols P, Bienenstock J. (2008): The D-alanine content of lipoteichoic acid is crucial for Lactobacillus plantarum mediated protection from visceral pain perception in a rat colorectal distension model. Neurogastroenterol Motil 20:843-50.
- Desbonnet L, Garrett L, Clarke G, Bienenstock J, Dinan TG. (2008): The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat. J Psychiatr Res (in press).
- Van der Kleij H, O’Mahony C, Shanahan F, O’Mahony L, Bienenstock J. (2008) Probioitics effects of Lactobacillus reuteri and Bifidobacterum infantis in murine models for colitis do not involve the vagus nerve Am J Physiol: Regul Integr Comp Physiol (in press)
- Kunze W A, Mao Y-K, Wang B, Huizinga J D, Ma X, Forsythe P, Bienenstock J. (2008): Lactobacillus reuteri enhances excitability of colonic AH neurons by inhibiting calcium dependent potassium channel opening. J Cell Mol Med (in press)
phone: (905) 522-1155 Extension 35203
email: bienens@mcmaster.ca
john bienenstock's website >>
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